Paula and Bobby
Parents of Lillie
Clubbing of Toes

Understanding limb related symptoms and features.
Symptoms may affect multiple parts of the body. Understanding which part of the body a symptom affects, can help us to better understand the potential underlying causes of a symptom, including a rare disease or genetic syndrome.
Limbs refer to the arms and legs of the body. They also include the hands and feet connected to the main limbs. Parts of the limbs include the fingers and toes, known as digits.
The limbs are an essential part of many different functions of the body, including movement, feeding and other necessary daily skills. Symptoms and features affecting the development and functioning of the limbs may also impact on these activities as well.
Generally, symptoms affecting the limbs may be seen with the naked eye. Although diagnosing a limb related symptom may involve different tests and assessments, both subjective and objective.
What is Clubbing of the toes?
Clubbing of the toes refers to a broadening of the toes. This can look like enlarged tips of the toes, sometimes with a redness or warmth as well. It can also affect the nails of the toes which may start to curve downward, or create a softening of the nail beds. It is usually most noticeable in the largest toe. It is also usually accompanied by a clubbing of the fingers as well.
Clubbing of the toes may be caused by a number of factors including but not limited to, celiac disease, cirrhosis of the liver or other liver diseases, dysentery, Graves disease, an overactive thyroid gland, or even by specific types of cancer including liver, gastrointestinal, and Hodgkin lymphoma.
What should I do next?
In some instances, clubbing of toes may be one of the features of a rare disease or genetic syndrome. In this case fast, targeted genetic analysis can give you a more accurate diagnosis.
Synonyms:
Clubbed toes
HPO:
0100760
Optional syndromes:
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Synonyms:
Clubbed toes
HPO:
-
0100760
Optional syndromes:
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