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Williams-Beuren syndrome (WBS)
O que é Williams-Beuren syndrome (WBS)?
A síndromes de Williams-Beuren é uma doença genética que se apresenta com uma face característica. As condições de saúde associadas a esse distúrbio do desenvolvimento incluem defeitos cardíacos e, especialmente, estenose aórtica supravalvar. Deficiência intelectual leve a moderada ou problemas de aprendizagem e muitas vezes traços de personalidade únicos caracterizam esta condição. Os pacientes costumam ter um rosto típico para essa síndrome, que inclui boca larga, lábios proeminentes e nariz pequeno. O distúrbio é raro e ocorre em aproximadamente 1 em 10,000 pessoas.
Sinônimos de Síndrome:
Quais mudanças genéticas causam Williams-Beuren syndrome (WBS)?
A exclusão de material genético de uma região específica do cromossomo 7 é considerada como causadora da síndromes de Williams-Beuren. Os genes tipicamente deletados incluem CLIP2, ELN, GTF2I, GTF2IRD1 e LIMK1. A deleção desses genes, e possivelmente de outros também, contribui para as características comportamentais únicas e outras dificuldades cognitivas das pessoas com síndrome de Williams-Beuren. A síndrome geralmente não é hereditária, mas ocorre durante a formação de células reprodutivas no pai do indivíduo afetado. No entanto, os indivíduos com a doença têm uma chance de 50% da doença ser herdada por seus futuros filhos.
A herança da microdeleção ocorre quando há uma deleção de vários genes em um cromossomo. O cromossomo específico no qual as deleções ocorrem determinará a síndrome que elas causam.
Genes, localizações e modos de herança
ELN, 7 q11. 23 - Autossômica dominante, microdeleção
MLXIPL, 7 q11. 23 - Autossômica dominante, microdeleção
GTF2IRD1, 7 q11. 23 - Dominante autossômico, microdeleção
GTF2I, 7 q11. 23 - Autossômica dominante, microdeleção
TBL2, 7 q11. 23 - Autossômica dominante, microdeleção
RFC2, 7 q11. 23 - Autosomal dominante, microdeleção
BAZ1B, 7 q11. 23 - Autossômica dominante, microdeleção
DLG4, 17 p13. 1 - Autosomal dominante, microdeleção
CLIP2, 7 q11. 23 - Autosomal Dominante, Microdeleção
LIMK1, 7 q11. 23 - Autossômica dominante, microdeleção
Número OMIM - 194050 (verifique a página OMIM para obter informações atualizadas)
Quais são os principais sintomas de Williams-Beuren syndrome (WBS)?
Os principais sintomas da síndromes de Williams-Beuren incluem traços faciais característicos, como boca larga, nariz pequeno arrebitado, dentes bem espaçados e lábios carnudos. DDA, ansiedade e fobias são comuns em indivíduos com a síndrome, assim como distúrbios de aprendizagem e atrasos na fala.
Os bebês podem apresentar cólicas e problemas de alimentação, bem como baixo peso ao nascer e tônus muscular.
Outras condições de saúde física podem incluir baixa estatura, hipermetropia e peito encovado. Anormalidades renais também são um sintoma da síndrome.
Possíveis traços / características clínicas:
Comprometimento cognitivo, Convulsão, Persistência do canal arterial, Cisto porencefálico, Microcefalia, Malformação de Arnold-Chiari, Defeito do septo atrial, Autismo, Transtorno de déficit de atenção e hiperatividade
Como alguém faz o teste de Williams-Beuren syndrome (WBS)?
O teste inicial para a
Com base nesta consulta clínica com um geneticista, as diferentes opções para testes genéticos serão compartilhadas e o consentimento será solicitado para testes adicionais.
Informações médicas sobre Williams-Beuren síndromes
Williams et al., first described this syndrome in 1961 and Beuren et al., (1962) expanded the phenotype. The main features are a characteristic face, heart defects, mental retardation with an outgoing personality and sometimes hypercalcaemia in infancy. The facial features consist of periorbital fullness, medial eyebrow flare, a stellate iris pattern, a flat nasal bridge, a flat malar region with full cheeks and lips, and a wide mouth with a long smooth philtrum.
Balacco-Gabrieli et al., (1985) reported a case with Rieger anomaly and megaloureter.
The facies may become coarser with age (Lopez-Rangel et al., 1992).
Hypercalcaemia may be difficult to document by the time the child has developed the full clinical features, but occasionally it is severe and persists. Enamel hypoplasia, strabismus and inguinal hernias are common. Pober et al., (1993) studied 40 children with Williams syndrome and found that seven (18%) had renal anomalies, however, only two had nephrocalcinosis - the remainder had abnormalities of size or shape of the kidneys. Mild renal artery stenosis was found in four out of nine patients studied, but only two had hypertension, which did not correlate with the renal artery stenosis.
Pankau et al., (1993) point out that radio-ulnar synostosis can be a feature in about 10% of cases (see also Bzduch, 1994). Curran et al., (1993) reported a disruption of the elastin gene at 7q11 in a family segregating for supravalvular aortic stenosis and a balanced translocation. Morris et al., (1993) suggested that the elastin gene on 7q11 may be involved in this syndrome, as cases with supravalvular aortic stenosis where disruption of the elastin gene has been demonstrated, have features of Williams syndrome. Ewart et al., (1993) identified hemizygosity of the elastin gene in four familial and five sporadic cases of Williams syndrome.
Ardinger et al., (1994) reported a 2-year-old boy with evidence of carotid and cerebral arterial stenosis with cerebral ischaemia.
There was a very high ESR and some response to steroids and the possibility of a vasculitis was considered. Two other cases of cerebrovascular narrowing in patients with Williams syndrome were reviewed from the literature. Further cases with cerebrovascular abnormalities have also been reported (Greally et al., 1994; Kaplan et al., 1995; Soper et al., 1995; Wollack et al., 1996). Pankau et al., (1996) examined 130 patients with Williams syndrome and found renal anomalies in 17.7%. 4-5% had renal agenesis or renal hypoplasia, 7% had a duplicated kidney, and around 6% had renal artery stenosis although hypertension was uncommon.
Pober and Filiano (1995) reported two cases with a Chiari type I malformation with fusion of the cervical spine. Nickerson et al., (1995) studied 44 clinically diagnosed cases and found elastin gene deletions in 40 (91%). Lowery et al., (1995) studied 235 cases with classic Williams syndrome and found deletions in 96%. Mari et al., (1995) reported similar findings in a series of 60 patients.
Mammi et al., (1996) reported a case who developed malignant hyperthermia after a general anaesthestic. They review the literature on anesthetic complications. Winter et al., (1996) review the eye findings in 152 patients. 77% of patients had blue irides, 74% showed a typical stellate iris pattern and 54% had strabismus. Occasional anomalies included cataracts, Rieger anomaly, ptosis and Marcus-Gunn phenomenon. Bird et al., (1996) reported 10 cases who suffered sudden death. Coronary artery stenosis and severe biventricular outflow tract obstruction seemed to be the main causes. Cases without deletions were felt to be clinically atypical. Joyce et al., (1996) found deletions in 22 out of 23 cases with classical Williams syndrome. The remaining patient had an 11q13.5-14.2 interstitial deletion. Perez Jurado et al., (1996) presented data suggesting that a gene or genes within the Williams deletion might be imprinted. Individuals who carry the deletion on the maternal 7 are smaller than those with deletions on the paternal chromosome 7. Dutly and Schinzel (1996) demonstrated that most deletions were due to unequal crossing over at meiosis with a small proportion being due to intrachromosomal (i.e. between chromatids) rearrangements. Tassabehji et al., (1996) showed that the LIM kinase gene (LIMK1) is also deleted in Williams cases. This gene codes for a novel protein kinase that is likely to be a component of an intracellular signalling pathway involved in brain development. Frangiskakis et al., (1996) showed that the LIM-kinase and elastin genes were deleted in two families with a partial Williams syndrome phenotype with developmental features of Williams syndrome and vascular abnormalities. They concluded that hemizygosity for the LIMK1 gene leads to impaired visuospatial constructive cognition.
Chodirker et al., (1997) reported five cases where a low maternal serum alpha fetoprotein level was noted in pregnancy. Scothorn and Butler (1997) reported a female case with precocious puberty. They suggest, anecdotally, that precocious puberty might be more common in Williams syndrome. Bawden et al., (1997) report their experience with using methylphenidate to treat hyperactivity in the disorder. Tsao and Westman (1997) reported two cases with infantile spasms. Fryssira et al., (1997) reported a male with normal intelligence and no features of Williams syndrome who had a deletion of the elastin gene by FISH analysis. Wang et al., (1997) reported another gene, homologous to the Drosophila frizzled wnt receptor, that seem to be included in Williams deletions. Osborne et al., (1997) reported deletions of the Syntaxin 1A gene in cases of Williams syndrome.
Mizugishi et al., (1998) reported a case with a visible 7q11.32-q21.11 deletion with Williams syndrome features also with infantile spasms. Sadler et al., (1998) showed that the mean carotid wall thickness in Williams syndrome was significantly greater than controls. Urban et al., (1996) and Baumer et al., (1998) presented data suggesting that deletions might be caused by unequal crossing over. Perez-Jurado et al., (1998) characterised the common deletion breakpoints and demonstrated a duplicated gene encoding BAP-135 a protein phosphorylated by Bruton's tryosine kinase in B-cell as well as the multiple functional transcription factor TFII-I. Arber et al., (1998) and Yang et al., (1998) showed that LIMK1 acts through phosphorylation of cofilin. Cofilin appears to be the enzyme required for actin depolymerization - a process involved in cell movement (Rosenblatt and Mitchison 1998). LIMK was deleted in 20 out of 20 Williams syndrome patients also deleted for the elastin gene. Sadler et al., (1993), Morris et al., (1993) and Ounap et al., (1998) reported convincing parent to child transmission, although most cases are sporadic.
Cherniske et al., (1999) reported evidence for early puberty. Botta et al., (1999) reported a patient not deleted for the Syntaxin 1A or frizzled genes with classical features of the condition. However, Tassabehji et al., (1999) presented data suggesting that the LIMK1 and STX1A genes were not involved in any of the Williams phenotype. They confirm that deletion of the ELN gene was responsible for the cardiological features of Williams syndrome. Tassabehji et al., (1999) showed that a transcription factor involved in skeletal muscle expression, GTF3, is located in the Williams critical region. Kara-Mostefa et al., (1999) reported sibs with an elastin gene deletion but normal parents. There was evidence suggesting maternal germ-line mosaicism.
Osborne et al., (2001) demonstrated a 1.5-base pair inversion polymorphism in families with Williams syndrome. Donnai and Karmiloff-Smith (2000) provide a good review of the molecular genetics and cognitive phenotype. Pamkau et al., (2001) reported two families with mother to child transmission, where the mothers were relatively mildly affected. Cunniff et al., (2001) set out suggestions for healthcare providers in children and young adults with Williams syndrome. There may also be stenosis of the abdominal aorta (Rose et al., 2001). Sadler et al., (2001) presented data suggesting that cardiovascular abnormalities were more severe in males.
The characteristic heart defect is a supravalvular aortic stenosis or a peripheral pulmonary artery stenosis. The cardiac abnormalities are well reviewed by Eronen et al., (2002). In 75 patients supravalvular aortic stenosis occurred in 73% of cases, pulmonary artery stenosis in 41% and an aortic or mitral valve defect in 11%. One case had tetralogy of Fallot. Renal artery stenosis can occur. Duba et al., (2002) reported a family segregating for a balanced t(7;16) (q11.23;q13). Phenotypes of translocation carriers in the family range from a hoarse voice, to a full Williams syndrome phenotype. The breakpoints disrupted intron 5 of the elastin gene, although without apparent deletion. The authors conclude that this suggests a position effect.
MRI scans of the brain are usually normal (Brinkmann et al., 1997), however, Faravelli et al., (2003) reported a child with the condition with microcephaly and a simplified gyral pattern of the parietal and frontal lobes. A deletion of 7q11.23 (see below) was demonstrated but it is not certain how large this was. Partsch et al., (2003) reported an estimated prevalence of precocious puberty of one in five to six girls with Williams syndrome (18.3%). Mean menarcheal age of 86 girls with Williams syndrome was 11.5 +/- 1.7 (+/-SD) years. Kalbhenn et al., (2003) reported a case with multiple infarctions and a spontaneous intracerebral haemorrhage. Stagi et al., (2003) reported two children with aplasia of the left lobe of the thyroid, and Bini and Pela (2004) reported a child with clinical signs of hypothyroidism. Karmiloff-Smith et al., (2003) studied a patient with supravalvular aortic stenosis and no physical or cognitive features of Williams syndrome who had an LIMK1 deletion. Gagliardi et al., (2003) studied a patients with an atypical smaller deletion who had a supravalvular aortic stenosis and vesicoureteric reflux with megaureter. There was normal development with mild language delay. The facial features were suggestive of Williams syndrome. The deletion included ELN, LIMK1 and at least part of the CYLN2 gene.
Giannotti et al., (2001) studied 63 cases with Williams syndrome, and found six with biopsy-proven coeliac disease (9.5%), compared to 0.54% in Italian students. Diverticulitis is relatively common in adults (Partsch et al., 2005). Metcalfe et al., (2005) reported a father and son with good clinical evidence of the condition, and both were found to have the common heterozygous deletion (which included FKBP6, known in the mouse to be involved in infertility). Scherer et al., (2005) reported two families with affected sibs and normal parents. One was the Kara-Mostefa et al., (1999) family. In both families, the WBSinv-1 variant, which is an inversion polymorphism, was present in the transmitting parent.
An adult patient, who had a stroke and evidence of a myocardial infarction was reported by Blanc et al., (2006). Ferland et al., (2006) reported a Williams patient with periventricular nodular heterotopia who had a deletion that was 1.5 Mb beyond the telomeric end of the typical Williams deletion, suggesting a more extended contiguous gene syndrome. See also Cammareri et al., (1999), Cambiaso et al., (2007) and Selicorni et al., (2006). These latter authors found 74% of their 96 patients had evidence of thyroid gland hypoplasia.
Craniosynostosis might occur (Ueda et al., 2015).
Walsh et al., (2017) described a male patient with Williams syndrome and congenital lobar emphysema. Wojcik et al., (2017) described a 49 years old male patient with Williams-Beuren syndrome and severe bullous lung emphysema.
Kruszka et. al. (2018) reviewed clinical findings in 137 patients from diverse populations. Most prevalent symptoms were intellectual disability (100%), malar flattening (99%), periorbital fullness (95%), long philtrum (93%), wide mouth (91%), growth abnormalities (91%), stellate iris (85%), small jaw (82%), short nose (74%), epicanthic folds (73%), broad eyebrows (63%) and strabismus (57%). The authors used facial analysis technology which was more accurate when considering the specific population.
* This information is courtesy of the L M D.
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