Laron syndrome

What is Laron syndrome?

This rare disease is a genetic syndrome that occurs when the body is incapable of utilizing growth hormones. As a result a short stature is one of its main symptoms.

The syndrome is not necessarily identified at birth, as affected infants are often born an average height. Height growth starts to slow usually in childhood and without treatment will continue into adulthood. Treatment for the limited height growth involves injections of a growth factor similar to insulin.

Those diagnosed with the syndrome may possibly have a reduced risk of developing cancer and diabetes type 2.

What gene changes cause Laron syndrome?

It is caused by changes to the GHR gene. It is inherited in an autosomal recessive pattern.

Autosomal recessive inheritance means an affected individual receives one copy of a mutated gene from each of their parents, giving them two copies of a mutated gene. Parents, who carry only one copy of the gene mutation will not generally show any symptoms, but have a 25% chance of passing the copies of the gene mutations onto each of their children.

What are the main symptoms of Laron syndrome?

The main symptom of the syndrome is a short stature with restricted height growth that is progressive, from childhood into adulthood. Short limbs, the arms and legs, are also a common feature.

Unique facial features associated with the syndrome include a protruding forehead, sunken bridge of the nose and a blue sclerae (bluish coloring of the whites of the eyes).

Reduced muscle strength and lower endurance are also symptoms. As are delayed puberty and obesity.

Hypoglycemia, low blood sugar and its related side effects, may be identified in infancy in affected individuals.

How does someone get tested for Laron syndrome?

The initial testing for Laron syndrome can begin with facial analysis screening, through the FDNA Telehealth telegenetics platform, which can identify the key markers of the syndrome and outline the need for further testing. A consultation with a genetic counselor and then a geneticist will follow.

Based on this clinical consultation with a geneticist, the different options for genetic testing will be shared and consent will be sought for further testing.

Get Faster and More Accurate Genetic Diagnosis!

More than 250,000 patients successfully analyzed!
Don't wait years for a diagnosis. Act now and save valuable time.

Start Here!

"Our road to a rare disease diagnosis was a 5-year journey that I can only describe as trying to take a road trip with no map. We didn’t know our starting point. We didn’t know our destination. Now we have hope."

Image

Paula and Bobby
Parents of Lillie

What is FDNA Telehealth?

FDNA Telehealth is a leading digital health company that provides faster access to accurate genetic analysis.

With a hospital technology recommended by leading geneticists, our unique platform connects patients with genetic experts to answer their most pressing questions and clarify any concerns they may have about their symptoms.

Benefits of FDNA Telehealth

Credibility

Our platform is currently used by over 70% of geneticists and has been used to diagnose over 250,000 patients worldwide.

Accessibility

FDNA Telehealth provides facial analysis and screening in minutes, followed by fast access to genetic counselors and geneticists.

Ease of Use

Our seamless process begins with an initial online diagnosis by a genetic counselor and follows by consultations with geneticists and genetic testing.

Accuracy & Precision

Advanced artificial intelligence (AI) capabilities and technology with a 90% accuracy rate for a more accurate genetic analysis.

Value for
Money

Faster access to genetic counselors, geneticists, genetic testing, and a diagnosis. As fast as within 24 hours if required. Save time and money.

Privacy & Security

We guarantee the utmost protection of all images and patient information. Your data is always safe, secure, and encrypted.

FDNA Telehealth can bring you closer to a diagnosis.
Schedule an online genetic counseling meeting within 72 hours!